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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
BELZUTIFAN

BELZUTIFAN


ATC L01XX74

ANTINEOPLASTIC
TREATMENT OF HIPPEL-LINDAU (VHL) DISEASE
INHIBITOR OF HYPOXIA-INDUCIBLE FACTOR-2 ALPHA (HIF-2A) TRANSCRIPTION FACTOR

ORAL

Cmax 3.4 MICROMOLAR

Tmax 1.5 HOUR

VD 130 LITER

PPB 45 PERCENT

Cl 7.3 LITER / HOUR

HT 14 HOUR

SOLUBILITY INSOLUBLE IN WATER

HYPOXIA-INDUCIBLE FACTOR-2 ALPHA

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