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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
ASCIMINIB

ASCIMINIB


ATC L01EA06

ANTINEOPLASTIC
ABL1 KINASE INHIBITOR
TREATMENT OF CHRONIC MYELOID LEUKEMIA (CML)
INHIBITS THE ABL1 KINASE ACTIVITY OF THE BCR-ABL1 FUSION PROTEIN

ORAL

Cmax 12.5 MICROMOLAR

Tmax 2.5 HOUR

VD 151 LITER

PPB 97 PERCENT

Cl 4.1 LITER / HOUR

HT 9 HOUR

ABL1 KINASE

PDB 5MO4 (ABL1 KINASE (T334I_D382N) IN COMPLEX WITH ASCIMINIB AND NILOTINIB)

LIGAND CODE = AY7 (link to the list of PDB complexes)

Download experimental 3D coordinates of AY7 with added hydrogens

More at DrugCentralANSM (in French)

Dailymed
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SIDER side effects

Chemical Probes Portal

ChEMBL
BindingDB
DrugBank



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