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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| ASCIMINIB
| ASCIMINIB | ANTINEOPLASTIC | ORAL | Cmax 12.5 MICROMOLAR Tmax 2.5 HOUR VD 151 LITER PPB 97 PERCENT Cl 4.1 LITER / HOUR HT 9 HOUR | ABL1 KINASE PDB 5MO4 (ABL1 KINASE (T334I_D382N) IN COMPLEX WITH ASCIMINIB AND NILOTINIB) LIGAND CODE = AY7 (link to the list of PDB complexes) Download experimental 3D coordinates of AY7 with added hydrogens | Tyrosine-protein kinase ABL1 UNIPROT P00519 more at DrugCentral | EMA | |||
