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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
MAVACAMTEN

MAVACAMTEN


ATC C01EB24

CARDIOVASCULAR
CARDIAC MYOSIN INHIBITOR
TREATMENT OF NEW YORK HEART ASSOCIATION (NYHA) II-III OBSTRUCTIVE HYPERTROPHIC CARDIOMYOPATHY (HCM)

ORAL

Tmax 1 HOUR

F 85 PERCENT

PPB 98 PERCENT

HT 180 HOUR

SOLUBILITY PRACTICALLY INSOLUBLE IN WATER AT PH 2-10

CARDIAC MYOSIN

PDB 8QYR (BETA-CARDIAC MYOSIN MOTOR DOMAIN IN THE PRE-POWERSTROKE STATE COMPLEXED TO MAVACAMTEN)

LIGAND CODE = XB2 (link to the list of PDB complexes)

Download experimental 3D coordinates of XB2 with added hydrogens

Myosin-7 UNIPROT P12883

more at DrugCentral

EMA

ANSM (in French)

Inxight Drugs
Dailymed
Drugs.com

SIDER side effects

Chemical Probes Portal

ChEMBL
BindingDB
DrugBank



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