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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| AVACOPAN
| AVACOPAN | IMMUNOSUPPRESSANTS | ORAL | Cmax 600 NANOMOLAR Tmax 2 HOUR VD 345 LITER PPB 99.9 PERCENT Cl 16.3 LITER / HOUR HT 97.6 HOUR SOLUBILITY PRACTICALLY INSOLUBLE IN WATER | C5AR PDB 6C1R (CRYSTAL STRUCTURE OF HUMAN C5A RECEPTOR IN COMPLEX WITH AN ORTHOSTERIC ANTAGONIST PMX53 AND AN ALLOSTERIC ANTAGONIST AVACOPAN) LIGAND CODE = EFD (link to the list of PDB complexes) Download experimental 3D coordinates of EFD with added hydrogens | C5a anaphylatoxin chemotactic receptor 1 UNIPROT P21730 more at DrugCentral | EMA | |||
