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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
LEVOKETOCONAZOLE

LEVOKETOCONAZOLE

GENITO
CORTISOL SYNTHESIS INHIBITOR INDICATED FOR THE TREATMENT OF ENDOGENOUS HYPERCORTISOLEMIA
CYTOCHROME CYP11B1 (11 BETA HYDROLASE), CYP11A1 (CHOLESTEROL SIDE-CHAIN CLEAVAGE) AND CYP17A1 (17 ALPHA HYDROLASE) INHIBITOR
SUBSTRATE OF INTESTINAL AND LIVER P-GPP

ORAL

Tmax 1.75 HOUR

VD 36 LITER

PPB 99.3 PERCENT

HT 3.75 HOUR

SOLUBILITY VERY SLIGHTLY SOLUBLE IN WATER AT PH 2

CYP11B1
CYP11A1
CYP17A1

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