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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
ABROCITINIB (has an active metabolite)

ABROCITINIB


ATC D11AH08

DERMATOLOGICALS
TREATMENT OF ATOPIC DERMATITIS
JANUS KINASE 1 (JAK1) INHIBITOR

ORAL

Tmax 1 HOUR

F 60 PERCENT

VD 100 LITER

PPB 64 PERCENT

HT 4 HOUR

SOLUBILITY 0.04 MILLIGRAM / MILLILITER

JAK1 KINASE

PDB 6BBU (CRYSTAL STRUCTURE OF JAK1 IN COMPLEX WITH COMPOUND 25)

LIGAND CODE = D7D (link to the list of PDB complexes)

Download experimental 3D coordinates of D7D with added hydrogens

More at DrugCentralANSM (in French)

Dailymed
Drugs.com

SIDER side effects

Chemical Probes Portal

ChEMBL
BindingDB
DrugBank

2 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
M ABROCITINIB (is an active metabolite)

ABROCITINIB


ATC D11AH08

DERMATOLOGICALS
TREATMENT OF ATOPIC DERMATITIS
JANUS KINASE 1 (JAK1) INHIBITOR

-

PPB 29 PERCENT

HT 4 HOUR

JAK1 KINASE

More at DrugCentralANSM (in French)

Dailymed
Drugs.com

SIDER side effects

Chemical Probes Portal

ChEMBL
BindingDB
DrugBank



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