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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| ABROCITINIB (has an active metabolite)
| ABROCITINIB | DERMATOLOGICALS | ORAL | Tmax 1 HOUR F 60 PERCENT VD 100 LITER PPB 64 PERCENT HT 4 HOUR SOLUBILITY 0.04 MILLIGRAM / MILLILITER | JAK1 KINASE PDB 6BBU (CRYSTAL STRUCTURE OF JAK1 IN COMPLEX WITH COMPOUND 25) LIGAND CODE = D7D (link to the list of PDB complexes) Download experimental 3D coordinates of D7D with added hydrogens | Tyrosine-protein kinase JAK1 UNIPROT P23458 more at DrugCentral | EMA | |||
| 2 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| M ABROCITINIB (is an active metabolite)
| ABROCITINIB | DERMATOLOGICALS | - | PPB 29 PERCENT HT 4 HOUR | JAK1 KINASE | Tyrosine-protein kinase JAK1 UNIPROT P23458 more at DrugCentral | EMA | |||
