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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| PACRITINIB
| PACRITINIB | ANTINEOPLASTIC | ORAL | Cmax 17.7 MICROMOLAR Tmax 4.5 HOUR VD 229 LITER PPB 98.8 PERCENT Cl 2.09 LITER / HOUR HT 27.7 HOUR | JAK2 FLT3 PDB 5LBZ (STRUCTURE OF THE HUMAN QUINONE REDUCTASE 2 (NQO2) IN COMPLEX WITH PACRITINIB) LIGAND CODE = 6T3 (link to the list of PDB complexes) Download experimental 3D coordinates of 6T3 with added hydrogens | Receptor-type tyrosine-protein kinase FLT3 UNIPROT P36888 FLT3 -- Tyrosine-protein kinase JAK2 UNIPROT O60674 JAK2 more at DrugCentral | EMA | |||
