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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| M REMDESIVIR (is an active metabolite)
| REMDESIVIR | ANTIINFECTIVES | - | Cmax 497 NANOMOLAR Tmax 1.75 HOUR PPB 2 PERCENT HT 27 HOUR | RNA POLYMERASE PDB 7BF6 (CRYSTAL STRUCTURE OF SARS-COV-2 MACRODOMAIN IN COMPLEX WITH REMDESIVIR METABOLITE GS-441524) LIGAND CODE = U08 (link to the list of PDB complexes) Download experimental 3D coordinates of U08 with added hydrogens | Replicase polyprotein 1ab UNIPROT P0DTD1 REP more at DrugCentral | EMA | |||
| 2 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| REMDESIVIR (has an active metabolite)
| REMDESIVIR | ANTIINFECTIVES | INTRAVENOUS | Cmax 3.7 MICROMOLAR Tmax 0.67 HOUR PPB 90.8 PERCENT HT 1 HOUR | RNA POLYMERASE | Replicase polyprotein 1ab UNIPROT P0DTD1 REP more at DrugCentral | EMA | |||
