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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| SOTORASIB
| SOTORASIB | ANTINEOPLASTIC | ORAL | Tmax 1 HOUR VD 211 LITER PPB 89 PERCENT Cl 26.2 LITER / HOUR HT 5 HOUR SOLUBILITY 0.03 MILLIGRAM PER MILLILITER | KRAS(G12C) | GTPase KRas UNIPROT P01116 KRAS more at DrugCentral | EMA | |||
