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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| INFIGRATINIB DISCONTINUED
| INFIGRATINIB | ANTINEOPLASTIC | ORAL | Cmax 504 NANOMOLAR Tmax 6 HOUR VD 1600 LITER PPB 96.8 PERCENT Cl 33.1 LITER / HOUR HT 33.5 HOUR SOLUBILITY PRACTICALLY INSOLUBLE IN WATER AT PH 6.8 | FGFR KINASE 1, 2, 3 AND 4 (IC50=1.1, 1, 2 AND 61 NANOMOLAR RESPECTIVELY) PDB 3TT0 (CO-STRUCTURE OF FIBROBLAST GROWTH FACTOR RECEPTOR 1 KINASE DOMAIN WITH 3-(2,6-DICHLORO-3,5-DIMETHOXY-PHENYL)-1-{6-[4-(4-ETHYL-PIPERAZIN-1-YL)-PHENYLAMINO]-PYRIMIDIN-4-YL}-1-METHYL-UREA (BGJ398)) LIGAND CODE = 07J (link to the list of PDB complexes) Download experimental 3D coordinates of 07J with added hydrogens | Fibroblast growth factor receptor 1 UNIPROT P11362 FGFR1 more at DrugCentral | EMA | |||
