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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
TRILACICLIB

TRILACICLIB


ATC V03AF12

ANTINEOPLASTIC
CDK4 AND CDK6 KINASE INHIBITOR
TO DECREASE THE INCIDENCE OF CHEMOTHERAPY-INDUCED MYELOSUPPRESSION

INTRAVENOUS

VD 1130 LITER

Cl 158 LITER / HOUR

HT 14 HOUR

CDK4
CDK6

Cyclin-dependent kinase 6 UNIPROT Q00534 CDK6 -- Cyclin-dependent kinase 4 UNIPROT P11802 CDK4

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