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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| TEPOTINIB
| TEPOTINIB | ANTINEOPLASTIC | ORAL | Cmax 2.62 MICROMOLAR Tmax 8 HOUR F 71.6 PERCENT VD 1038 LITER PPB 98 PERCENT Cl 23.8 LITER / HOUR HT 32 HOUR | MET KINASE PDB 4R1V (IDENTIFICATION AND OPTIMIZATION OF PYRIDAZINONES AS POTENT AND SELECTIVE C-MET KINASE INHIBITORS) LIGAND CODE = 3E8 (link to the list of PDB complexes) Download experimental 3D coordinates of 3E8 with added hydrogens | Hepatocyte growth factor receptor UNIPROT P08581 MET more at DrugCentral | EMA | |||
