Cheminformatic Tools and Databases for Pharmacology

session 62201 - Total of 1 hits - Display   hits per page:

Add another drug(s) by one keyword:
Exemple: “nib“ and click on the Search button (do not press Enter on the keyboard)

1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
LONAFARNIB

LONAFARNIB


ATC A16AX20

VARIOUS
FARNESYL PROTEIN TRANSFERASE INHIBITOR
TREATMENT OF PROCESSING-DEFICIENT PROGEROID LAMINOPATHIES
TO REDUCE THE RISK OF MORTALITY IN HUTCHINSON-GILFORD PROGERIA SYNDROME (HGPS)

ORAL

Cmax 2.8 MICROMOLAR

Tmax 2 HOUR

VD 97.4 LITER

PPB 99 PERCENT

HT 5 HOUR

FARNESYL PROTEIN TRANSFERASE

PDB 1O5M (STRUCTURE OF FPT BOUND TO THE INHIBITOR SCH66336)

LIGAND CODE = 336 (link to the list of PDB complexes)

Download experimental 3D coordinates of 336 with added hydrogens

Unknown - more at DrugCentralANSM (in French)

Dailymed
Drugs.com

SIDER side effects

Chemical Probes Portal

ChEMBL
BindingDB
DrugBank



Copyright © 2019 Université Côte d'Azur CNRS - All rights reserved
  | Contact |