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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| TIRBANIBULIN
| TIRBANIBULIN | DERMATOLOGICALS | TOPICAL | Cmax 0.78 NANOMOLAR Tmax 7 HOUR PPB 88 PERCENT | TUBULIN PDB 6KNZ (CRYSTAL STRUCTURE OF T2R-TTL-KXO1 COMPLEX) LIGAND CODE = DN0 (link to the list of PDB complexes) Download experimental 3D coordinates of DN0 with added hydrogens | Tubulin beta chain UNIPROT P07437 TUBB more at DrugCentral | EMA | |||
