| | ||||||||||
| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| M RIPRETINIB (is an active metabolite)
| RIPRETINIB | ANTINEOPLASTIC | - | Cmax 1.62 MICROMOLAR Tmax 15.6 HOUR VD 507 LITER PPB 99.8 PERCENT Cl 17.5 LITER / HOUR HT 17.8 HOUR | PROTO-ONCOGENE RECEPTOR TYROSINE KINASE (KIT) | Mast,stem cell growth factor receptor Kit UNIPROT P10721 KIT -- Platelet-derived growth factor receptor alpha UNIPROT P16234 PDGFRA more at DrugCentral | EMA | |||
| 2 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| RIPRETINIB (has an active metabolite)
| RIPRETINIB | ANTINEOPLASTIC | ORAL | Cmax 1.49 MICROMOLAR Tmax 4 HOUR VD 307 LITER PPB 99.8 PERCENT Cl 15.3 LITER / HOUR HT 14.8 HOUR SOLUBILITY PRACTICALLY INSOLUBLE IN WATER | PROTO-ONCOGENE RECEPTOR TYROSINE KINASE (KIT) | Mast,stem cell growth factor receptor Kit UNIPROT P10721 KIT -- Platelet-derived growth factor receptor alpha UNIPROT P16234 PDGFRA more at DrugCentral | EMA | |||
