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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
PEMIGATINIB

PEMIGATINIB


ATC L01EX20

ANTINEOPLASTIC
FGFR1, 2 AND 3 KINASE INHIBITOR
TREATMENT OF METASTATIC CHOLANGIOCARCINOMA WITH A FIBROBLAST GROWTH FACTOR RECEPTOR 2 (FGFR2)

ORAL

Cmax 236 NANOMOLAR

Tmax 1.13 HOUR

VD 235 LITER

PPB 90.6 PERCENT

Cl 10.6 LITER / HOUR

HT 15.4 HOUR

FGFR1
FGFR2
FGFR3

Fibroblast growth factor receptor 3 INHIBITOR P22607 (FGFR3_HUMAN)ANSM (in French)

Dailymed
Drugs.com

SIDER side effects

Chemical Probes Portal

ChEMBL
BindingDB
DrugBank



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