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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that the equation t1/2 = VD / Cl * 0.693 was usedPrimary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
CAPMATINIB

CAPMATINIB


ATC L01EX17

ANTINEOPLASTIC
TREATMENT OF METASTATIC NON-SMALL CELL LUNG CANCER (NSCLC)
MET KINASE INHIBITOR

ORAL

Tmax 1.5 HOUR

F 70 PERCENT

VD 164 LITER

PPB 96 PERCENT

Cl 24 LITER / HOUR

HT 6.5 HOUR

SOLUBILITY LOW SOLUBILITY IN WATER

MET

Hepatocyte growth factor receptor UNIPROT P08581 MET

more at DrugCentral

EMA

ANSM (in French)

Inxight Drugs
Dailymed
Drugs.com

SIDER side effects

Chemical Probes Portal

ChEMBL
BindingDB
DrugBank



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