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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that the equation t1/2 = VD / Cl * 0.693 was used | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| OPICAPONE
| OPICAPONE | NERVOUS SYSTEM | ORAL | Tmax 2 HOUR PPB 99 PERCENT HT 1.5 HOUR SOLUBILITY LIMITED AQUEOUS SOLUBILITY | CATECHOL-O-METHYLTRANSFERASE (COMT) PDB 7XJB (RAT-COMT, OPICAPONE,SAM AND MG BOND) LIGAND CODE = DNI (link to the list of PDB complexes) Download experimental 3D coordinates of DNI with added hydrogens | Catechol O-methyltransferase UNIPROT P21964 COMT more at DrugCentral | EMA | |||
