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session 45613 - Total of 4 hits - Display hits per page:

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1	INN	Class	Route (list)	PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)	Primary Target and PDB code of Protein-Drug complex	Targets from DrugCentral	Links
FENFLURAMINE (has an active metabolite)	FENFLURAMINE	ATC A08AA02 ATC N03AX26 NERVOUS SYSTEM TREATMENT OF SEIZURES ASSOCIATED WITH DRAVET SYNDROME INCREASE EXTRACELLULAR LEVELS OF SEROTONIN THROUGH INTERACTION WITH SEROTONIN TRANSPORTER PROTEINS EXHIBIT AGONIST ACTIVITY AT SEROTONIN 5HT-2 RECEPTORS	ORAL	Cmax 294.2 NANOMOLAR Tmax 4.5 HOUR F 71 PERCENT VD 773.5 LITER (65 KILOGRAM) PPB 50 PERCENT Cl 24.8 LITER / HOUR HT 20 HOUR	SEROTONIN TRANSPORTER	Sodium-dependent serotonin transporter UNIPROT P31645 SLC6A4 more at DrugCentral	EMA ANSM (in French) Inxight Drugs Dailymed Drugs.com SIDER side effects Chemical Probes Portal ChEMBL BindingDB DrugBank
2	INN	Class	Route (list)	PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)	Primary Target and PDB code of Protein-Drug complex	Targets from DrugCentral	Links
FENFLURAMINE (has an active metabolite)	FENFLURAMINE	ATC A08AA02 ATC N03AX26 NERVOUS SYSTEM TREATMENT OF SEIZURES ASSOCIATED WITH DRAVET SYNDROME INCREASE EXTRACELLULAR LEVELS OF SEROTONIN THROUGH INTERACTION WITH SEROTONIN TRANSPORTER PROTEINS EXHIBIT AGONIST ACTIVITY AT SEROTONIN 5HT-2 RECEPTORS	ORAL	Cmax 294.2 NANOMOLAR Tmax 4.5 HOUR F 71 PERCENT VD 773.5 LITER (65 KILOGRAM) PPB 50 PERCENT Cl 24.8 LITER / HOUR HT 20 HOUR	SEROTONIN TRANSPORTER	Sodium-dependent serotonin transporter UNIPROT P31645 SLC6A4 more at DrugCentral	EMA ANSM (in French) Inxight Drugs Dailymed Drugs.com SIDER side effects Chemical Probes Portal ChEMBL BindingDB DrugBank
3	INN	Class	Route (list)	PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)	Primary Target and PDB code of Protein-Drug complex	Targets from DrugCentral	Links
M FENFLURAMINE (is an active metabolite)	FENFLURAMINE	ATC A08AA02 ATC N03AX26 NERVOUS SYSTEM TREATMENT OF SEIZURES ASSOCIATED WITH DRAVET SYNDROME INCREASE EXTRACELLULAR LEVELS OF SEROTONIN THROUGH INTERACTION WITH SEROTONIN TRANSPORTER PROTEINS EXHIBIT AGONIST ACTIVITY AT SEROTONIN 5HT-2 RECEPTORS	-		SEROTONIN TRANSPORTER	Sodium-dependent serotonin transporter UNIPROT P31645 SLC6A4 more at DrugCentral	EMA ANSM (in French) Inxight Drugs Dailymed Drugs.com SIDER side effects Chemical Probes Portal ChEMBL BindingDB DrugBank
4	INN	Class	Route (list)	PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)	Primary Target and PDB code of Protein-Drug complex	Targets from DrugCentral	Links
M FENFLURAMINE (is an active metabolite)	FENFLURAMINE	ATC A08AA02 ATC N03AX26 NERVOUS SYSTEM TREATMENT OF SEIZURES ASSOCIATED WITH DRAVET SYNDROME INCREASE EXTRACELLULAR LEVELS OF SEROTONIN THROUGH INTERACTION WITH SEROTONIN TRANSPORTER PROTEINS EXHIBIT AGONIST ACTIVITY AT SEROTONIN 5HT-2 RECEPTORS	-		SEROTONIN TRANSPORTER	Sodium-dependent serotonin transporter UNIPROT P31645 SLC6A4 more at DrugCentral	EMA ANSM (in French) Inxight Drugs Dailymed Drugs.com SIDER side effects Chemical Probes Portal ChEMBL BindingDB DrugBank