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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
LASMIDITAN

LASMIDITAN


ATC N02CC08

NERVOUS SYSTEM
SEROTONIN (5-HT) 1F RECEPTOR AGONIST
TREATMENT OF MIGRAINE WITH OR WITHOUT AURA IN ADULTS

ORAL

Tmax 1.8 HOUR

PPB 57.5 PERCENT

HT 5.7 HOUR

SOLUBILITY SPARINGLY SOLUBLE IN WATER

SEROTONIN (5-HT) 1F RECEPTOR

PDB 7EXD (LASMIDITAN-BOUND SEROTONIN 1F (5-HT1F) RECEPTOR-GI PROTEIN COMPLEX)

LIGAND CODE = 05X (link to the list of PDB complexes)

Download experimental 3D coordinates of 05X with added hydrogens

5-hydroxytryptamine receptor 1F UNIPROT P30939 HTR1F

more at DrugCentral

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ANSM (in French)

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