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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| M OZANIMOD (is an active metabolite)
| OZANIMOD | IMMUNOSUPPRESSANTS | - | Cmax 19.4 NANOMOLAR PPB 99.8 PERCENT HT 264 HOUR | SPHINGOSINE 1- PHOSPHATE RECEPTORS S1P 1 AND 5 | Sphingosine 1-phosphate receptor 1 UNIPROT P21453 S1PR1 -- Sphingosine 1-phosphate receptor 5 UNIPROT Q9H228 S1PR5 more at DrugCentral | EMA | |||
| 2 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| OZANIMOD (has an active metabolite)
| OZANIMOD | IMMUNOSUPPRESSANTS | ORAL | Cmax 0.6 NANOMOLAR Tmax 7 HOUR VD 5590 LITER PPB 98.2 PERCENT Cl 192 LITER / HOUR HT 21 HOUR SOLUBILITY FREELY SOLUBLE IN WATER | SPHINGOSINE 1- PHOSPHATE RECEPTORS S1P 1 AND 5 PDB 7EW0 (CRYO-EM STRUCTURE OF OZANIMOD -BOUND SPHINGOSINE-1-PHOSPHATE RECEPTOR 1 IN COMPLEX WITH GI PROTEIN) LIGAND CODE = JEU (link to the list of PDB complexes) Download experimental 3D coordinates of JEU with added hydrogens | Sphingosine 1-phosphate receptor 1 UNIPROT P21453 S1PR1 -- Sphingosine 1-phosphate receptor 5 UNIPROT Q9H228 S1PR5 more at DrugCentral | EMA | |||
