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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
ISTRADEFYLLINE

ISTRADEFYLLINE


ATC N04CX01

NERVOUS SYSTEM
ADENOSINE RECEPTOR ANTAGONIST INDICATED AS ADJUNCTIVE TREATMENT TO LEVODOPA/CARBIDOPA IN ADULT PATIENTS WITH PARKINSON’S DISEASE (PD) EXPERIENCING OFF EPISODES

ORAL

Tmax 4 HOUR

VD 557 LITER

PPB 98 PERCENT

Cl 4.6 LITER / HOUR

HT 83 HOUR

SOLUBILITY 0.6 MICROGRAM PER MILLILITER IN WATER

ADENOSINE RECEPTOR A2A

Adenosine receptor A2a ANTAGONIST P29274 AA2AR_HUMANANSM (in French)

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