Cheminformatic Tools and Databases for Pharmacology

session 90788 - Total of 1 hits - Display   hits per page:

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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
TAFAMIDIS

TAFAMIDIS


ATC N07XX08

CARDIOVASCULAR
TRANSTHYRETIN STABILIZERS
TREATMENT OF THE CARDIOMYOPATHY OF WILD TYPE OR HEREDITARY TRANSTHYRETIN-MEDIATED AMYLOIDOSIS
TAFAMIDIS BINDS TO TTR AT THE THYROXINE BINDING SITES

ORAL

Tmax 4 HOUR

VD 18.5 LITER

PPB 99 PERCENT

Cl 0.263 LITER / HOUR

HT 49 HOUR

TRANSTHYRETIN

PDB 3TCT (STRUCTURE OF WILD-TYPE TTR)

LIGAND CODE = 3MI (link to the list of PDB complexes)

Download experimental 3D coordinates of 3MI with added hydrogens

Transthyretin TTHY_HUMAN P02766ANSM (in French)

Dailymed
Drugs.com

SIDER side effects

Chemical Probes Portal

ChEMBL
BindingDB
DrugBank



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