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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
TALAZOPARIB

TALAZOPARIB


ATC L01XX60

ANTINEOPLASTIC
INHIBITOR OF POLYADENOSINE 5’-DIPHOSPHORIBOSE POLYMERASE (PARP) PARP1 AND PARP2

ORAL

Cmax 43 NANOMOLAR

Tmax 1.5 HOUR

VD 420 LITER

PPB 74 PERCENT

Cl 6.45 LITER / HOUR

HT 90 HOUR

POLYADENOSINE 5-DIPHOSPHORIBOSE POLYMERASE (PARP)

PDB 4UND (HUMAN ARTD1 (PARP1))

LIGAND CODE = 2YQ (link to the list of PDB complexes)

Download experimental 3D coordinates of 2YQ with added hydrogens

Poly [ADP-ribose] polymerase 1 P09874ANSM (in French)

Dailymed
Drugs.com

SIDER side effects

Chemical Probes Portal

ChEMBL
BindingDB
DrugBank



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