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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
BREXANOLONE

BREXANOLONE


ATC N06AX29

NERVOUS SYSTEM
A NEUROACTIVE STEROID GAMMA-AMINOBUTYRIC ACID (GABA) A RECEPTOR POSITIVE MODULATOR
TREATMENT OF POSTPARTUM DEPRESSION (PPD)

INTRAVENOUS

Cmax 163 NANOMOLAR

VD 195 LITER (65 KILOGRAM)

PPB 99 PERCENT

Cl 65 LITER / HOUR (65 KILOGRAM)

HT 9 HOUR

GAMMA-AMINOBUTYRIC ACID (GABA) A RECEPTOR

PDB 8G4N (NATIVE GABA-A RECEPTOR FROM THE MOUSE BRAIN, ALPHA1-BETA2-GAMMA2 SUBTYPE, IN COMPLEX WITH GABA, ZOLPIDEM, AND ENDOGENOUS NEUROSTEROIDS)

LIGAND CODE = Y4B (link to the list of PDB complexes)

Download experimental 3D coordinates of Y4B with added hydrogens

Gamma-aminobutyric acid receptor subunit alpha-1 UNIPROT P14867 GABRA1

more at DrugCentral

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