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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
GILTERITINIB

GILTERITINIB


ATC L01XE54

ANTINEOPLASTIC
TREATMENT OF ACUTE MYELOID LEUKEMIA (AML) WITH A FLT3 MUTATION
TYROSINE KINASES INHIBITOR
INHIBITOR OF FMS-LIKE TYROSINE KINASE 3 (FLT3) INCLUDING FLT3-D835Y AND FLT3-ITD-D835Y MUTATIONS

ORAL

Cmax 0.67 MICROMOLAR

Tmax 5 HOUR

VD 1092 LITER

PPB 94 PERCENT

Cl 14.85 LITER / HOUR

HT 113 HOUR

SOLUBILITY SPARINGLY SOLUBLE IN WATER

FMS-LIKE TYROSINE KINASE 3 (FLT3)

PDB 6JQR (CRYSTAL STRUCTURE OF FLT3 IN COMPLEX WITH GILTERITINIB)

LIGAND CODE = C6F (link to the list of PDB complexes)

Download experimental 3D coordinates of C6F with added hydrogens

Receptor-type tyrosine-protein kinase FLT3 P36888 (FLT3_HUMAN)ANSM (in French)

Dailymed
Drugs.com

SIDER side effects

Chemical Probes Portal

ChEMBL
BindingDB
DrugBank



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