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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
DACOMITINIB

DACOMITINIB


ATC L01XE47

ANTINEOPLASTIC
IRREVERSIBLE KINASE INHIBITOR OF EGFR FAMILY (EGFR/HER1, HER2 AND HER4)
COMPLEX PDB 4I23
TREATMENT OF METASTATIC NON-SMALL CELL LUNG CANCER (NSCLC)
ALSO INHIBITED THE ACTIVITY OF DDR1, EPHA6, LCK, DDR2, AND MNK1 AT CLINICALLY RELEVANT CONCENTRATIONS

ORAL

Cmax 230 NANOMOLAR

Tmax 6 HOUR

F 80 PERCENT

VD 1889 LITER

PPB 98 PERCENT

Cl 24.9 LITER / HOUR

HT 70 HOUR

EGFR KINASE

Epidermal growth factor receptor P00533ANSM (in French)

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