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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that the equation t1/2 = VD / Cl * 0.693 was used | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| IVOSIDENIB
| IVOSIDENIB | ANTINEOPLASTIC | ORAL | Cmax 7.7 MICROMOLAR Tmax 3 HOUR VD 234 LITER PPB 94 PERCENT Cl 4.3 LITER / HOUR HT 93 HOUR SOLUBILITY PRACTICALLY INSOLUBLE IN AQUEOUS SOLUTIONS BETWEEN PH 1.2 AND 7.4 | ISOCITRATE DEHYDROGENASE-1 (IDH1) PDB 8T7O (CRYSTAL STRUCTURE OF THE R132H MUTANT OF IDH1 BOUND TO AG-120) LIGAND CODE = IV3 (link to the list of PDB complexes) Download experimental 3D coordinates of IV3 with added hydrogens | Isocitrate dehydrogenase NADP cytoplasmic UNIPROT O75874 IDH1 more at DrugCentral | EMA | |||
