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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
DUVELISIB

DUVELISIB


ATC L01EM04

ANTINEOPLASTIC
PI3K DELTA AND PI3K GAMMA KINASE INHIBITOR
TREATMENT OF REFRACTORY CHRONIC LYMPHOCYTIC LEUKEMIA (CLL)

ORAL

Cmax 3.6 MICROMOLAR

Tmax 1.5 HOUR

F 42 PERCENT

VD 28.5 LITER

PPB 98 PERCENT

Cl 4.2 LITER / HOUR

HT 4.7 HOUR

SOLUBILITY PRACTICALLY INSOLUBLE IN WATER

PI3K

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform O00329 (PK3CD_HUMAN)ANSM (in French)

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SIDER side effects

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ChEMBL
BindingDB
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