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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
LAROTRECTINIB

LAROTRECTINIB


ATC L01XE53

ANTINEOPLASTIC
KINASE INHIBITOR
TREATMENT OF SOLID TUMOR
INHIBITOR OF THE TROPOMYOSIN RECEPTOR KINASES (TRK), TRKA, TRKB, AND TRKC

ORAL

Cmax 1.84 MICROMOLAR

Tmax 1 HOUR

F 34 PERCENT

VD 48 LITER

PPB 70 PERCENT

Cl 98 LITER / HOUR

HT 2.9 HOUR

SOLUBILITY FREELY SOLUBLE IN WATER AT PH 6.8

TROPOMYOSIN RECEPTOR KINASE

High affinity nerve growth factor receptor P04629ANSM (in French)

Dailymed
Drugs.com

SIDER side effects

Chemical Probes Portal

ChEMBL
BindingDB
DrugBank



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