| | ||||||||||
| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| LAROTRECTINIB
| LAROTRECTINIB | ANTINEOPLASTIC | ORAL | Cmax 1.84 MICROMOLAR Tmax 1 HOUR F 34 PERCENT VD 48 LITER PPB 70 PERCENT Cl 98 LITER / HOUR HT 2.9 HOUR SOLUBILITY FREELY SOLUBLE IN WATER AT PH 6.8 | TROPOMYOSIN RECEPTOR KINASE | High affinity nerve growth factor receptor UNIPROT P04629 NTRK1 -- BDNF,NT-3 growth factors receptor UNIPROT Q16620 NTRK2 more at DrugCentral | EMA | |||
