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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
GLASDEGIB

GLASDEGIB


ATC L01XX63

ANTINEOPLASTIC
INHIBITOR OF THE HEDGEHOG PATHWAY
INHIBITS SMOOTHENED TRANSMEMBRANE PROTEIN (SMO)
TREATMENT OF ACUTE MYELOID LEUKEMIA (AML)

ORAL

Cmax 3.3 MICROMOLAR

Tmax 1.55 HOUR

F 77 PERCENT

VD 188 LITER

PPB 91 PERCENT

Cl 6.45 LITER / HOUR

HT 17.4 HOUR

SOLUBILITY SOLUBLE IN WATER (1.7 MILLIGRAM PER MILLIMITER)

SMOOTHENED (SMO)

Smoothened homolog Q99835ANSM (in French)

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ChEMBL
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