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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
PRUCALOPRIDE

PRUCALOPRIDE


ATC A06AX05

METABOLISM
SEROTONIN-4 (5-HT4) RECEPTOR AGONIST
TREATMENT OF CHRONIC IDIOPATHIC CONSTIPATION (CIC)

ORAL

Cmax 19 NANOMOLAR

Tmax 2.5 HOUR

F 90 PERCENT

VD 567 LITER

PPB 30 PERCENT

Cl 19 LITER / HOUR

HT 24 HOUR

SOLUBILITY HIGHLY SOLUBLE IN ACIDIC AQUEOUS MEDIA

SEROTONIN-4 (5-HT4)

5-hydroxytryptamine receptor 4 5HT4R_HUMAN Q13639 5-hydroxytryptamine receptor 3A 5HT3A_HUMAN P46098 D(4) dopamine receptor DRD4_HUMAN P21917ANSM (in French)

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