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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
SIPONIMOD

SIPONIMOD


ATC L04AA42

NERVOUS SYSTEM
A SPHINGOSINE 1-PHOSPHATE RECEPTOR MODULATOR (SIP RECEPTORS 1 AND 5)
TREATMENT OF RELAPSING FORMS OF MULTIPLE SCLEROSIS (MS)

REDUCES THE NUMBER OF LYMPHOCYTES IN PERIPHERAL BLOOD

ORAL

Cmax 58.8 NANOMOLAR

Tmax 4 HOUR

F 84 PERCENT

VD 124 LITER

PPB 99.9 PERCENT

Cl 3.11 LITER / HOUR

HT 30 HOUR

SPHINGOSINE 1-PHOSPHATE RECEPTOR (S1P)

Sphingosine 1-phosphate receptor 1 P21453ANSM (in French)

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