Cheminformatic Tools and Databases for Pharmacology

session 13607 - Total of 2 hits - Display   hits per page:

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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
M TRICLABENDAZOLE (is an active metabolite)

TRICLABENDAZOLE


ATC P02BX04

ANTIPARASITIC
ANTHELMINTIC
TREATMENT OF FASCIOLIASIS
TRICLABENDAZOLE AND ITS METABOLITES ARE ACTIVE AGAINST THE IMMATURE AND MATURE WORMS

-

Cmax 38.6 MICROMOLAR

Tmax 3.5 HOUR

VD 65 LITER (65 KILOGRAM)

PPB 98.4 PERCENT

HT 14 HOUR

Unknown

more at DrugCentral

EMA

ANSM (in French)

Inxight Drugs
Dailymed
Drugs.com

SIDER side effects

Chemical Probes Portal

ChEMBL
BindingDB
DrugBank

2 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
TRICLABENDAZOLE (has an active metabolite)

TRICLABENDAZOLE


ATC P02BX04

ANTIPARASITIC
ANTHELMINTIC
TREATMENT OF FASCIOLIASIS
TRICLABENDAZOLE AND ITS METABOLITES ARE ACTIVE AGAINST THE IMMATURE AND MATURE WORMS

ORAL

Cmax 1.16 MICROMOLAR

Tmax 3.5 HOUR

PPB 96.7 PERCENT

HT 8 HOUR

PDB 7ERI (CRYSTAL STRUCTURE OF V30M-TTR IN COMPLEX WITH TRICLABENDAZOLE)

LIGAND CODE = JA9 (link to the list of PDB complexes)

Download experimental 3D coordinates of JA9 with added hydrogens

Unknown

more at DrugCentral

EMA

ANSM (in French)

Inxight Drugs
Dailymed
Drugs.com

SIDER side effects

Chemical Probes Portal

ChEMBL
BindingDB
DrugBank



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