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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| AMIFAMPRIDINE
| AMIFAMPRIDINE | NERVOUS SYSTEM | ORAL | Tmax 1.3 HOUR PPB 25.3 PERCENT Cl 181 LITER / HOUR HT 2.15 HOUR SOLUBILITY FREELY SOLUBLE IN WATER | POTASSIUM CHANNELS PDB 5NOW (STRUCTURE OF CYCLOPHILIN A IN COMPLEX WITH PYRIDINE-3,4-DIAMINE) LIGAND CODE = L89 (link to the list of PDB complexes) Download experimental 3D coordinates of L89 with added hydrogens | Voltage-gated potassium channel UNIPROT O43525 KCNQ3 more at DrugCentral | EMA | |||
