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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
AMIFAMPRIDINE

AMIFAMPRIDINE


ATC N07XX05

NERVOUS SYSTEM
TREATMENT OF LAMBERT-EATON MYASTHENIC SYNDROME (LEMS)
BROAD SPECTRUM VOLTAGE-GATED POTASSIUM CHANNEL BLOCKER
THE MECHANISM OF ACTION HAS NOT BEEN FULLY ELUCIDATED

ORAL

Tmax 1.3 HOUR

PPB 25.3 PERCENT

Cl 181 LITER / HOUR

HT 2.15 HOUR

SOLUBILITY FREELY SOLUBLE IN WATER

POTASSIUM CHANNELS

PDB 5NOW (STRUCTURE OF CYCLOPHILIN A IN COMPLEX WITH PYRIDINE-3,4-DIAMINE)

LIGAND CODE = L89 (link to the list of PDB complexes)

Download experimental 3D coordinates of L89 with added hydrogens

Voltage-gated potassium channel family (KCA10_HUMAN O43525)ANSM (in French)

Dailymed
Drugs.com

SIDER side effects

Chemical Probes Portal

ChEMBL
BindingDB
DrugBank



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