Cheminformatic Tools and Databases for Pharmacology

session 28280 - Total of 2 hits - Display   hits per page:

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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
APALUTAMIDE (has an active metabolite)

APALUTAMIDE


ATC L02BB05

ANTINEOPLASTIC
ANDROGEN RECEPTOR INHIBITOR INDICATED FOR THE TREATMENT OF PATIENTS WITH NON-METASTATIC CASTRATION-RESISTANT PROSTATE CANCER

ORAL

Cmax 12.5 MICROMOLAR

Tmax 3 HOUR

F 100 PERCENT

VD 276 LITER

PPB 96 PERCENT

Cl 1.3 LITER / HOUR

HT 72 HOUR

SOLUBILITY PRACTICALLY INSOLUBLE IN AQUEOUS MEDIA OVER A WIDE RANGE OF PH VALUES

ANDROGEN RECEPTOR

NUCLEAR RECEPTOR ANDR_HUMAN INHIBITOR P10275ANSM (in French)

Dailymed
Drugs.com

SIDER side effects

Chemical Probes Portal

ChEMBL
BindingDB
DrugBank

2 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
M APALUTAMIDE (is an active metabolite)

APALUTAMIDE


ATC L02BB05

ANTINEOPLASTIC
ANDROGEN RECEPTOR INHIBITOR INDICATED FOR THE TREATMENT OF PATIENTS WITH NON-METASTATIC CASTRATION-RESISTANT PROSTATE CANCER
N-DESMETHYL APALUTAMIDE, IS A LESS POTENT INHIBITOR OF AR, AND EXHIBITED ONE-THIRD THE ACTIVITY

-

Cmax 12.7 MICROMOLAR

PPB 95 PERCENT

ANDROGEN RECEPTOR

NUCLEAR RECEPTOR ANDR_HUMAN INHIBITOR P10275ANSM (in French)

Dailymed
Drugs.com

SIDER side effects

Chemical Probes Portal

ChEMBL
BindingDB
DrugBank



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