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session 96517 - Total of 2 hits - Display hits per page:

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1	INN	Class	Route (list)	PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)	Primary Target and PDB code of Protein-Drug complex	Targets from DrugCentral	Links
APALUTAMIDE (has an active metabolite)	APALUTAMIDE	ATC L02BB05 ANTINEOPLASTIC ANDROGEN RECEPTOR INHIBITOR INDICATED FOR THE TREATMENT OF PATIENTS WITH NON-METASTATIC CASTRATION-RESISTANT PROSTATE CANCER	ORAL	Cmax 12.5 MICROMOLAR Tmax 3 HOUR F 100 PERCENT VD 276 LITER PPB 96 PERCENT Cl 1.3 LITER / HOUR HT 72 HOUR SOLUBILITY PRACTICALLY INSOLUBLE IN AQUEOUS MEDIA OVER A WIDE RANGE OF PH VALUES	ANDROGEN RECEPTOR	Androgen receptor UNIPROT P10275 AR more at DrugCentral	EMA ANSM (in French) Inxight Drugs Dailymed Drugs.com SIDER side effects Chemical Probes Portal ChEMBL BindingDB DrugBank
2	INN	Class	Route (list)	PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)	Primary Target and PDB code of Protein-Drug complex	Targets from DrugCentral	Links
M APALUTAMIDE (is an active metabolite)	APALUTAMIDE	ATC L02BB05 ANTINEOPLASTIC ANDROGEN RECEPTOR INHIBITOR INDICATED FOR THE TREATMENT OF PATIENTS WITH NON-METASTATIC CASTRATION-RESISTANT PROSTATE CANCER N-DESMETHYL APALUTAMIDE, IS A LESS POTENT INHIBITOR OF AR, AND EXHIBITED ONE-THIRD THE ACTIVITY	-	Cmax 12.7 MICROMOLAR PPB 95 PERCENT	ANDROGEN RECEPTOR	Androgen receptor UNIPROT P10275 AR more at DrugCentral	EMA ANSM (in French) Inxight Drugs Dailymed Drugs.com SIDER side effects Chemical Probes Portal ChEMBL BindingDB DrugBank