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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| TEZACAFTOR
| TEZACAFTOR | RESPIRATORY SYSTEM | ORAL | Cmax 11.4 MICROMOLAR Tmax 4 HOUR VD 271 LITER PPB 99 PERCENT Cl 1.31 LITER / HOUR HT 15 HOUR SOLUBILITY PRACTICALLY INSOLUBLE IN WATER | CFTR CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR PDB 7SV7 (THE COMPLEX OF PHOSPHORYLATED HUMAN CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR (CFTR) WITH ATP, MG AND TEZACAFTOR (VX-661)) LIGAND CODE = CV6 (link to the list of PDB complexes) Download experimental 3D coordinates of CV6 with added hydrogens | Cystic fibrosis transmembrane conductance regulator UNIPROT P13569 CFTR more at DrugCentral | EMA | |||
