Cheminformatic Tools and Databases for Pharmacology

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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
TEZACAFTOR

TEZACAFTOR


ATC R07AX31

RESPIRATORY SYSTEM
CYSTIC FIBROSIS WITH F508DEL MUTATION
POTENTIATOR
METABOLITE M1 HAS SIMILAR POTENCY TO THAT OF TEZACAFTOR

ORAL

Cmax 11.4 MICROMOLAR

Tmax 4 HOUR

VD 271 LITER

PPB 99 PERCENT

Cl 1.31 LITER / HOUR

HT 15 HOUR

SOLUBILITY PRACTICALLY INSOLUBLE IN WATER

CFTR CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR

ION CHANNEL CFTR_HUMAN CHAPERONE P13569ANSM (in French)

Dailymed
Drugs.com

SIDER side effects

Chemical Probes Portal

ChEMBL
BindingDB
DrugBank



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