Cheminformatic Tools and Databases for Pharmacology

session 99693 - Total of 1 hits - Display   hits per page:

Add another drug(s) by one keyword:
Exemple: “nib“ and click on the Search button (do not press Enter on the keyboard)

1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
ACALABRUTINIB

ACALABRUTINIB


ATC L01XE51

ANTINEOPLASTIC
BRUTON TYROSINE KINASE (BTK) INHIBITOR
TREATMENT OF MANTLE CELL LYMPHOMA (MCL)
FORM A COVALENT BOND WITH A CYSTEINE RESIDUE IN THE BTK ACTIVE SITE
ACP-5862 IS THE MAJOR ACTIVE METABOLITE BUT ACTIVITY IS 50 PERCENT LESS POTENT

ORAL

Cmax 694 NANOMOLAR

Tmax 0.75 HOUR

F 25 PERCENT

VD 34 LITER

PPB 97.5 PERCENT

Cl 159 LITER / HOUR

HT 0.9 HOUR

SOLUBILITY PRACTICALLY INSOLUBLE IN WATER AT PH VALUES ABOVE 6

BRUTON TYROSINE KINASE (BTK)

KINASE BTK_HUMAN INHIBITOR Q06187ANSM (in French)

Dailymed
Drugs.com

SIDER side effects

Chemical Probes Portal

ChEMBL
BindingDB
DrugBank



Copyright © 2019 Université Côte d'Azur CNRS - All rights reserved
  | Contact |