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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
LETERMOVIR

LETERMOVIR


ATC J05AX18

ANTIINFECTIVES
DNA TERMINASE COMPLEX (PUL51, PUL56, AND PUL89) INHIBITOR
PROPHYLAXIS OF CYTOMEGALOVIRUS (CMV) INFECTION

ORAL INTRAVENOUS

Cmax 22.7 MICROMOLAR

Tmax 1.25 HOUR

F 94 PERCENT

VD 45.5 LITER

PPB 99 PERCENT

HT 12 HOUR

SOLUBILITY VERY SLIGHTLY SOLUBLE IN WATER

DNA TERMINASE COMPLEX

ENZYME TRM1_HCMVM INHIBITOR F5HC79 TRM2_HCMVM INHIBITOR F5HGI9 TRM3_HCMVM INHIBITOR F5HCU8ANSM (in French)

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