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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
COPANLISIB

COPANLISIB


ATC L01XX61

ANTINEOPLASTIC
PHOSPHATIDYLINOSITOL-3-KINASE (PI3K) INHIBITOR WITH INHIBITORY ACTIVITY PREDOMINANTLY AGAINST PI3K-ALPHA AND PI3K-DELTA ISOFORMS EXPRESSED IN MALIGNANT B CELLS
TREATMENT OF FOLLICULAR LYMPHOMA

INTRAVENOUS

Cmax 964 NANOMOLAR

VD 871 LITER

PPB 84.2 PERCENT

Cl 17.9 LITER / HOUR

HT 39.1 HOUR

PHOSPHATIDYLINOSITOL-3-KINASE (PI3K)

PDB 5G2N (X-RAY STRUCTURE OF PI3KINASE GAMMA IN COMPLEX WITH COPANLISIB)

LIGAND CODE = 6E2 (link to the list of PDB complexes)

Download experimental 3D coordinates of 6E2 with added hydrogens

KINASE PK3CA_HUMAN INHIBITOR P42336 PK3CD_HUMAN INHIBITOR O00329ANSM (in French)

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