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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| VABORBACTAM
| VABORBACTAM | ANTIINFECTIVES | INTRAVENOUS | Cmax 170.7 MICROMOLAR (4 GRAM) VD 18.6 LITER PPB 33 PERCENT Cl 10.9 LITER / HOUR HT 1.68 HOUR | BETA-LACTAMASE PDB 4XUZ (STRUCTURE OF CTX-M-15 BOUND TO RPX-7009 AT 1.5 A) LIGAND CODE = 4D6 (link to the list of PDB complexes) Download experimental 3D coordinates of 4D6 with added hydrogens | beta-lactamase UNIPROT A8DS27 more at DrugCentral | EMA | |||
