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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
SECNIDAZOLE

SECNIDAZOLE


ATC P01AB07
ATC J01RA07

ANTIPARASITIC
A NITROIMIDAZOLE ANTIMICROBIAL
TREATMENT OF BACTERIAL VAGINOSIS IN ADULT WOMEN
5-NITROIMIDAZOLES ENTER THE BACTERIAL CELL AS AN INACTIVE PRODRUG WHERE THE NITRO GROUP IS REDUCED BY BACTERIAL ENZYMES TO RADICAL ANIONS. IT IS BELIEVED THAT THESE RADICAL ANIONS INTERFERE WITH BACTERIAL DNA SYNTHESIS OF SUSCEPTIBLE ISOLATES

ORAL

Cmax 245.3 MICROMOLAR

Tmax 4 HOUR

VD 42 LITER

PPB 5 PERCENT

Cl 1.5 LITER / HOUR

HT 17 HOUR

DNA

3-oxoacyl-[acyl-carrier-protein] synthase 3 C3TDZ2ANSM (in French)

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