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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| FOSTAMATINIB (has an active metabolite)
| FOSTAMATINIB | ANTINEOPLASTIC | ORAL | SOLUBILITY SLIGHTLY SOLUBLE IN WATER | PHOSPHATASE PDB 4O75 (CRYSTAL STRUCTURE OF THE FIRST BROMODOMAIN OF HUMAN BRD4 IN COMPLEX WITH FOSTAMATINIB) LIGAND CODE = 2RC (link to the list of PDB complexes) Download experimental 3D coordinates of 2RC with added hydrogens | Tyrosine-protein kinase SYK UNIPROT P43405 SYK more at DrugCentral | EMA | |||
| 2 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| M FOSTAMATINIB (is an active metabolite)
| FOSTAMATINIB | ANTINEOPLASTIC | - | Cmax 1.17 MICROMOLAR Tmax 1.5 HOUR F 55 PERCENT VD 256 LITER PPB 98.3 PERCENT HT 15 HOUR | TYROSINE KINASE SYK PDB 3FQS (CRYSTAL STRUCTURE OF SPLEEN TYROSINE KINASE COMPLEXED WITH R406) LIGAND CODE = 585 (link to the list of PDB complexes) Download experimental 3D coordinates of 585 with added hydrogens | Tyrosine-protein kinase SYK UNIPROT P43405 SYK more at DrugCentral | EMA | |||
