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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
LOFEXIDINE

LOFEXIDINE


ATC N07BC04

NERVOUS SYSTEM
CENTRAL ALPHA-2 ADRENERGIC AGONIST
INDICATED FOR MITIGATION OF OPIOID WITHDRAWAL SYMPTOMS TO FACILITATE ABRUPT OPIOID DISCONTINUATION IN ADULTS

ORAL

Cmax 3.16 NANOMOLAR

Tmax 4 HOUR

F 72 PERCENT (0.36 MILLIGRAM)

VD 480 LITER

PPB 55 PERCENT

Cl 17.6 LITER / HOUR

HT 12 HOUR

SOLUBILITY FREELY SOLUBLE IN WATER

ALPHA-2 ADRENERGIC RECEPTOR

GPCR ADA2A_HUMAN AGONIST P08913ANSM (in French)

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