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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
ABEMACICLIB

ABEMACICLIB


ATC L01XE50

ANTINEOPLASTIC
TREATMENT OF ADVANCED OR METASTATIC BREAST CANCER
INHIBITOR OF CYCLIN-DEPENDENT KINASES 4 AND 6 (CDK4 AND CDK6)

ORAL

Tmax 8 HOUR

F 45 PERCENT (200 MILLIGRAM)

VD 690.3 LITER

PPB 96.3 PERCENT

HT 18.3 HOUR

CYCLIN-DEPENDENT KINASES 4 AND 6 (CDK4 AND CDK6)

PDB 5L2S (THE X-RAY CO-CRYSTAL STRUCTURE OF HUMAN CDK6 AND ABEMACICLIB)

LIGAND CODE = 6ZV (link to the list of PDB complexes)

Download experimental 3D coordinates of 6ZV with added hydrogens

KINASE CDK4_HUMAN INHIBITOR P11802 CDK6_HUMAN INHIBITOR Q00534ANSM (in French)

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