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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
BARICITINIB

BARICITINIB


ATC L04AA37

IMMUNOMODULATING
JANUS KINASES (JAKS) INHIBITOR
TREATMENT OF ADULT PATIENTS WITH MODERATELY TO SEVERELY ACTIVE RHEUMATOID ARTHRITIS

ORAL

Tmax 1 HOUR

F 80 PERCENT

VD 76 LITER

PPB 50 PERCENT

Cl 8.9 LITER / HOUR

HT 12 HOUR

JANUS KINASES (JAK)

PDB 4W9X (CRYSTAL STRUCTURE OF BMP-2-INDUCIBLE KINASE IN COMPLEX WITH BARICITINIB)

LIGAND CODE = 3JW (link to the list of PDB complexes)

Download experimental 3D coordinates of 3JW with added hydrogens

KINASE JAK1_HUMAN INHIBITOR P23458 JAK2_HUMAN INHIBITOR O60674ANSM (in French)

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SIDER side effects

Chemical Probes Portal

ChEMBL
BindingDB
DrugBank



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