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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| LATANOPROSTENE BUNOD (has an active metabolite)
| LATANOPROSTENE BUNOD | SENSORY | OPHTHALMIC | Prostaglandin F2-alpha receptor UNIPROT P43088 PTGFR more at DrugCentral | EMA | |||||
| 2 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| M LATANOPROST (is an active metabolite)
| LATANOPROST | SENSORY | - | VD 10.4 LITER (65 KILOGRAM) Cl 27.3 LITER / HOUR (65 KILOGRAM) HT 0.28 HOUR | PROSTAGLANDIN F2-ALPHA RECEPTOR PDB 8XJM (LATANOPROST ACID BOUND PROSTAGLANDIN F2-ALPHA RECEPTOR-GQ PROTEIN COMPLEX) LIGAND CODE = 7WT (link to the list of PDB complexes) Download experimental 3D coordinates of 7WT with added hydrogens | Prostaglandin F2-alpha receptor UNIPROT P43088 PTGFR more at DrugCentral | EMA | |||
