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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
MAYTANSINE

MAYTANSINE
ADO-TRASTUZUMAB EMTANSINE
NATURAL MOLECULE (link)


ATC L01XC14

ANTINEOPLASTIC
TREATMENT OF PATIENTS WITH HER2-POSITIVE, METASTATIC BREAST CANCER WHO PREVIOUSLY RECEIVED TRASTUZUMAB AND A TAXANE, SEPARATELY OR IN COMBINATION
HER2-TARGETED ANTIBODY-DRUG CONJUGATE (ADC)
EMTANSINE REFERS TO THE MCC-DM1
DM1 IS A MAYTANSINE DERIVATIVE AND MCC IS STABLE THIOETHER LINKER (4-[N-MALEIMIDOMETHYL] CYCLOHEXANE-1-CARBOXYLATE)
LEAD TO THE RELEASE OF DM1 A MICROTUBULE INHIBITOR

INJECTION

Cmax 6 NANOMOLAR

PPB 93 PERCENT

TUBULIN

TUBULIN TBB1_HUMAN INHIBITOR P04350ANSM (in French)

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