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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
CALICHEAMICIN

CALICHEAMICIN
INOTUZUMAB OZOGAMICIN
GEMTUZUMAB OZOGAMICIN


ATC L01XC05
ATC L01XC26

ANTINEOPLASTIC
TREATMENT OF ADULTS WITH RELAPSED OR REFRACTORY B-CELL PRECURSOR ACUTE LYMPHOBLASTIC LEUKEMIA (ALL)
CD33- OR CD22-DIRECTED ANTIBODY-DRUG CONJUGATE (ADC)
RELEASE OF N-ACETYL-GAMMA-CALICHEAMICIN THAT CAUSES DOUBLE-STRANDED DNA BREAKS

INJECTION

PPB 97 PERCENT

DNA

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