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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
LEVOLEUCOVORIN (has an active metabolite)

LEVOLEUCOVORIN
LEUCOVORIN


ATC B03AD04
ATC B03AD01
ATC B03AD02
ATC B03AD05
ATC B03AD03
ATC B03BB01
ATC V04CX02
ATC B03BB51
ATC B03AE02
ATC B03AE01

VARIOUS
ANTIANEMIC
ANTIDOTE TO FOLIC ACID ANTAGONISTS
ANTINEOPLASTIC ADJUNCTS
RESCUE AFTER HIGH-DOSE METHOTREXATE THERAPY IN OSTEOSARCOMA
USE IN COMBINATION CHEMOTHERAPY WITH 5-FLUOROURACIL
RAPIDLY ABSORBED AND ENTERS THE GENERAL BODY POOL OF REDUCED FOLATES
CONVERTED TO 5-METHYLTETRAHYDROFOLIC ACID (5-METHYL-THF)

INJECTION ORAL INTRAVENOUS

VD 16.2 LITER (65 KILOGRAM)

PPB 91 PERCENT

Cl 22.6 LITER / HOUR (65 KILOGRAM)

HT 1.3 HOUR

SOLUBILITY SOLUBLE IN WATER

PDB 3UWL (CRYSTAL STRUCTURE OF ENTEROCCOCUS FAECALIS THYMIDYLATE SYNTHASE (EFTS) IN COMPLEX WITH 5-FORMYL TETRAHYDROFOLATE)

LIGAND CODE = FOZ (link to the list of PDB complexes)

Download experimental 3D coordinates of FOZ with added hydrogens

Unknown

more at DrugCentral

EMA

ANSM (in French)

Inxight Drugs
Dailymed
Drugs.com

SIDER side effects

Chemical Probes Portal

ChEMBL
BindingDB
DrugBank



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